Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells

Tumor microenvironment is hypoxic, which can cause resistance to chemotherapy, but the detailed mechanisms remain elusive. Here we find that mild hypoxia (5% O(2)) further increases cisplatin resistance in the already resistant HepG2/DDP but not the sensitive HepG2 cells. We find that Nrf2 is respon...

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Detalles Bibliográficos
Autores principales: Jin, Xin, Gong, Liansheng, Peng, Ying, Li, Le, Liu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835028/
https://www.ncbi.nlm.nih.gov/pubmed/33290263
http://dx.doi.org/10.18632/aging.202137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835028/
https://www.ncbi.nlm.nih.gov/pubmed/33290263
http://dx.doi.org/10.18632/aging.202137

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