TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei

TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. However, its impact on TJs of ciliated epithelia is sparsely investigated. Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. We...

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Detalles Bibliográficos
Autores principales: Schilpp, Carolin, Lochbaum, Robin, Braubach, Peter, Jonigk, Danny, Frick, Manfred, Dietl, Paul, Wittekindt, Oliver H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Signaling and Cell Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835204/
https://www.ncbi.nlm.nih.gov/pubmed/33386991
http://dx.doi.org/10.1007/s00424-020-02501-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835204/
https://www.ncbi.nlm.nih.gov/pubmed/33386991
http://dx.doi.org/10.1007/s00424-020-02501-2

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