Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here...

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Detalles Bibliográficos
Autores principales: Zhou, Huanjiao Jenny, Qin, Lingfeng, Jiang, Quan, Murray, Katie N., Zhang, Haifeng, Li, Busu, Lin, Qun, Graham, Morven, Liu, Xinran, Grutzendler, Jaime, Min, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835246/
https://www.ncbi.nlm.nih.gov/pubmed/33495460
http://dx.doi.org/10.1038/s41467-020-20774-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835246/
https://www.ncbi.nlm.nih.gov/pubmed/33495460
http://dx.doi.org/10.1038/s41467-020-20774-0

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