Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) is downregulated in CHS cells treated with bromodomain and extraterminal domain (BET) inhibitor JQ1. However, the precise role of YAP1...

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Detalles Bibliográficos
Autores principales: Zhang, Huan-Tian, Gui, Tao, Liu, Ri-Xu, Tong, Kui-Leung, Wu, Chong-Jie, Li, Zhenyan, Huang, Xun, Xu, Qiu-Tong, Yang, Jie, Tang, Wang, Sang, Yuan, Liu, Wanting, Liu, Ning, Ross, Ryan D., He, Qing-Yu, Zha, Zhen-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835383/
https://www.ncbi.nlm.nih.gov/pubmed/33495462
http://dx.doi.org/10.1038/s41419-021-03416-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835383/
https://www.ncbi.nlm.nih.gov/pubmed/33495462
http://dx.doi.org/10.1038/s41419-021-03416-1

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