Heterologous Expression of Pseudouridimycin and Description of the Corresponding Minimal Biosynthetic Gene Cluster

Pseudouridimycin (PUM) was recently discovered from Streptomyces sp. DSM26212 as a novel bacterial nucleoside analog that competes with UTP for access to the RNA polymerase (RNAP) active site, thereby inhibiting bacterial RNAP by blocking transcription. This represents a novel antibacterial mode of...

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Detalles Bibliográficos
Autores principales: Böhringer, Nils, Patras, Maria A., Schäberle, Till F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835738/
https://www.ncbi.nlm.nih.gov/pubmed/33478059
http://dx.doi.org/10.3390/molecules26020510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835738/
https://www.ncbi.nlm.nih.gov/pubmed/33478059
http://dx.doi.org/10.3390/molecules26020510

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