Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments †

The serine biosynthetic pathway is a key element contributing to tumor proliferation. In recent years, targeting of phosphoglycerate dehydrogenase (PHGDH), the first enzyme of this pathway, intensified and revealed to be a promising strategy to develop new anticancer drugs. Among attractive PHGDH in...

Descripción completa

Detalles Bibliográficos
Autores principales: Spillier, Quentin, Ravez, Séverine, Dochain, Simon, Vertommen, Didier, Thabault, Léopold, Feron, Olivier, Frédérick, Raphaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835887/
https://www.ncbi.nlm.nih.gov/pubmed/33477510
http://dx.doi.org/10.3390/molecules26020477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835887/
https://www.ncbi.nlm.nih.gov/pubmed/33477510
http://dx.doi.org/10.3390/molecules26020477

Ejemplares similares