The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Supplemental oxygen therapy with supraphysiological concentrations of oxygen (hyperoxia; >21% O(2)) is a life-saving intervention for patients experiencing respiratory distress. However, prolonged exposure to hyperoxia can compromise bacterial clearance processes, due to oxidative stress-mediated...

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Detalles Bibliográficos
Autores principales: Gauthier, Alex G., Wu, Jiaqi, Lin, Mosi, Sitapara, Ravikumar, Kulkarni, Abhijit, Thakur, Ganesh A., Schmidt, Edward E., Perron, Jeanette C., Ashby, Charles R., Mantell, Lin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835977/
https://www.ncbi.nlm.nih.gov/pubmed/33477969
http://dx.doi.org/10.3390/antiox10010135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835977/
https://www.ncbi.nlm.nih.gov/pubmed/33477969
http://dx.doi.org/10.3390/antiox10010135

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