Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

Decitabine (DAC) is a well-known DNA methyltransferase inhibitor, which has been widely used for the treatment of acute myeloid leukemia (AML). However, in addition to hypomethylation, DAC in AML is also involved in cell metabolism, apoptosis, and immunity. The TP53-induced glycolysis and apoptosis...

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Detalles Bibliográficos
Autores principales: Li, Lanzhu, Liu, Wenjie, Sun, Qian, Zhu, Han, Hong, Ming, Qian, Sixuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836025/
https://www.ncbi.nlm.nih.gov/pubmed/33532040
http://dx.doi.org/10.1155/2021/8877460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836025/
https://www.ncbi.nlm.nih.gov/pubmed/33532040
http://dx.doi.org/10.1155/2021/8877460

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