The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera

The current COVID-19 (coronavirus disease 19) pandemic, caused by SARS-CoV-2, disproportionally affects the elderly and people with comorbidities like obesity and associated type 2 diabetes mellitus. Small animal models are crucial for the successful development and validation of antiviral vaccines,...

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Detalles Bibliográficos
Autores principales: Rathnasinghe, Raveen, Jangra, Sonia, Cupic, Anastasija, Martínez-Romero, Carles, Mulder, Lubbertus C.F., Kehrer, Thomas, Yildiz, Soner, Choi, Angela, Mena, Ignacio, De Vrieze, Jana, Aslam, Sadaf, Stadlbauer, Daniel, Meekins, David A., McDowell, Chester D., Balaraman, Velmurugan, Richt, Juergen A., De Geest, Bruno G., Miorin, Lisa, Krammer, Florian, Simon, Viviana, García-Sastre, Adolfo, Schotsaert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836140/
https://www.ncbi.nlm.nih.gov/pubmed/33501468
http://dx.doi.org/10.1101/2021.01.19.21249592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836140/
https://www.ncbi.nlm.nih.gov/pubmed/33501468
http://dx.doi.org/10.1101/2021.01.19.21249592

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