Furin cleavage sites naturally occur in coronaviruses

The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike protei...

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Detalles Bibliográficos
Autores principales: Wu, Yiran, Zhao, Suwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836551/
https://www.ncbi.nlm.nih.gov/pubmed/33340798
http://dx.doi.org/10.1016/j.scr.2020.102115
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author Wu, Yiran
Zhao, Suwen
author_facet Wu, Yiran
Zhao, Suwen
author_sort Wu, Yiran
collection PubMed
description The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2.
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spelling pubmed-78365512021-01-26 Furin cleavage sites naturally occur in coronaviruses Wu, Yiran Zhao, Suwen Stem Cell Res Article The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2. The Author(s). Published by Elsevier B.V. 2021-01 2020-12-09 /pmc/articles/PMC7836551/ /pubmed/33340798 http://dx.doi.org/10.1016/j.scr.2020.102115 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wu, Yiran
Zhao, Suwen
Furin cleavage sites naturally occur in coronaviruses
title Furin cleavage sites naturally occur in coronaviruses
title_full Furin cleavage sites naturally occur in coronaviruses
title_fullStr Furin cleavage sites naturally occur in coronaviruses
title_full_unstemmed Furin cleavage sites naturally occur in coronaviruses
title_short Furin cleavage sites naturally occur in coronaviruses
title_sort furin cleavage sites naturally occur in coronaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836551/
https://www.ncbi.nlm.nih.gov/pubmed/33340798
http://dx.doi.org/10.1016/j.scr.2020.102115
work_keys_str_mv AT wuyiran furincleavagesitesnaturallyoccurincoronaviruses
AT zhaosuwen furincleavagesitesnaturallyoccurincoronaviruses

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