The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes

Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβ(n−x)) independently of BACE1, which generates the N-Terminus of Aβ starting with Asp1 (Aβ(1−x)). A candidate protease for the gener...

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Detalles Bibliográficos
Autores principales: Oberstein, Timo Jan, Utz, Janine, Spitzer, Philipp, Klafki, Hans Wolfgang, Wiltfang, Jens, Lewczuk, Piotr, Kornhuber, Johannes, Maler, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836726/
https://www.ncbi.nlm.nih.gov/pubmed/33510618
http://dx.doi.org/10.3389/fnmol.2020.615740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836726/
https://www.ncbi.nlm.nih.gov/pubmed/33510618
http://dx.doi.org/10.3389/fnmol.2020.615740

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