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The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes
Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβ(n−x)) independently of BACE1, which generates the N-Terminus of Aβ starting with Asp1 (Aβ(1−x)). A candidate protease for the gener...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836726/ https://www.ncbi.nlm.nih.gov/pubmed/33510618 http://dx.doi.org/10.3389/fnmol.2020.615740 |