Polycations and polyanions in SARS-CoV-2 infection

We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the vi...

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Autores principales: Ginsburg, I., Fibach, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837050/
https://www.ncbi.nlm.nih.gov/pubmed/33412501
http://dx.doi.org/10.1016/j.mehy.2020.110470
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author Ginsburg, I.
Fibach, E.
author_facet Ginsburg, I.
Fibach, E.
author_sort Ginsburg, I.
collection PubMed
description We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids.
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spelling pubmed-78370502021-01-26 Polycations and polyanions in SARS-CoV-2 infection Ginsburg, I. Fibach, E. Med Hypotheses Article We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids. The Authors. Published by Elsevier Ltd. 2021-01 2021-01-04 /pmc/articles/PMC7837050/ /pubmed/33412501 http://dx.doi.org/10.1016/j.mehy.2020.110470 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ginsburg, I.
Fibach, E.
Polycations and polyanions in SARS-CoV-2 infection
title Polycations and polyanions in SARS-CoV-2 infection
title_full Polycations and polyanions in SARS-CoV-2 infection
title_fullStr Polycations and polyanions in SARS-CoV-2 infection
title_full_unstemmed Polycations and polyanions in SARS-CoV-2 infection
title_short Polycations and polyanions in SARS-CoV-2 infection
title_sort polycations and polyanions in sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837050/
https://www.ncbi.nlm.nih.gov/pubmed/33412501
http://dx.doi.org/10.1016/j.mehy.2020.110470
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