Detecting SARS-CoV-2 3CLpro expression and activity using a polyclonal antiserum and a luciferase-based biosensor

The need to stem the current outbreak of SARS-CoV-2 responsible for COVID-19 is driving the search for inhibitors that will block coronavirus replication and pathogenesis. The coronavirus 3C-like protease (3CLpro) encoded in the replicase polyprotein is an attractive target for antiviral drug develo...

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Detalles Bibliográficos
Autores principales: O'Brien, Amornrat, Chen, Da-Yuan, Hackbart, Matthew, Close, Brianna J., O'Brien, Timothy E., Saeed, Mohsan, Baker, Susan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837110/
https://www.ncbi.nlm.nih.gov/pubmed/33548599
http://dx.doi.org/10.1016/j.virol.2021.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837110/
https://www.ncbi.nlm.nih.gov/pubmed/33548599
http://dx.doi.org/10.1016/j.virol.2021.01.010

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