ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

The small molecule ISRIB antagonizes the activation of the integrated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(αP). ISRIB and eIF2(αP) bind distinct sites in their common target, eIF2B, a guanine nucleotide exchange factor for eIF2. We have found that ISRIB-media...

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Detalles Bibliográficos
Autores principales: Zyryanova, Alisa F., Kashiwagi, Kazuhiro, Rato, Claudia, Harding, Heather P., Crespillo-Casado, Ana, Perera, Luke A., Sakamoto, Ayako, Nishimoto, Madoka, Yonemochi, Mayumi, Shirouzu, Mikako, Ito, Takuhiro, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837216/
https://www.ncbi.nlm.nih.gov/pubmed/33220178
http://dx.doi.org/10.1016/j.molcel.2020.10.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837216/
https://www.ncbi.nlm.nih.gov/pubmed/33220178
http://dx.doi.org/10.1016/j.molcel.2020.10.031

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