Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase

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The superfamily 1 helicase nonstructural protein 13 (nsp13) is required for SARS-CoV-2 replication. The mechanism and regulation of nsp13 has not been explored at the single-molecule level. Specifically, force-dependent unwinding experiments have yet to be performed for any coronavirus helicase. Her...

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Detalles Bibliográficos
Autores principales: Mickolajczyk, Keith J., Shelton, Patrick M.M., Grasso, Michael, Cao, Xiaocong, Warrington, Sara E., Aher, Amol, Liu, Shixin, Kapoor, Tarun M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837305/
https://www.ncbi.nlm.nih.gov/pubmed/33340543
http://dx.doi.org/10.1016/j.bpj.2020.11.2276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837305/
https://www.ncbi.nlm.nih.gov/pubmed/33340543
http://dx.doi.org/10.1016/j.bpj.2020.11.2276

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