Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

Rett syndrome is a devastating childhood neurological disorder caused by mutations in MECP2. Of the many symptoms, motor deterioration is a significant problem for patients. In mice, deleting Mecp2 from the cortex or basal ganglia causes motor dysfunction, hypoactivity, and tremor, which are abnorma...

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Detalles Bibliográficos
Autores principales: Achilly, Nathan P, He, Ling-jie, Kim, Olivia A, Ohmae, Shogo, Wojaczynski, Gregory J, Lin, Tao, Sillitoe, Roy V, Medina, Javier F, Zoghbi, Huda Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837679/
https://www.ncbi.nlm.nih.gov/pubmed/33494858
http://dx.doi.org/10.7554/eLife.64833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837679/
https://www.ncbi.nlm.nih.gov/pubmed/33494858
http://dx.doi.org/10.7554/eLife.64833

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