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Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling
Inflammatory caspase-11 senses and is activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis that has critical role in defensing against bacterial infection, whereas its excess activation under pathogenic circumstances may cause various inflammatory diseases. However, there are fe...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838020/ https://www.ncbi.nlm.nih.gov/pubmed/33532184 http://dx.doi.org/10.1016/j.apsb.2020.07.014 |