Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer

Romidepsin (FK228), a histone deacetylase inhibitor (HDACi), has anti-tumor effects against several types of solid tumors. Studies have suggested that HDACi could upregulate PD-L1 expression in tumor cells and change the state of anti-tumor immune responses in vivo. However, the influence of enhance...

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Detalles Bibliográficos
Autores principales: Shi, Yehui, Fu, Ying, Zhang, Xin, Zhao, Gang, Yao, Yuan, Guo, Yan, Ma, Gang, Bai, Shuai, Li, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838139/
https://www.ncbi.nlm.nih.gov/pubmed/32632663
http://dx.doi.org/10.1007/s00262-020-02653-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838139/
https://www.ncbi.nlm.nih.gov/pubmed/32632663
http://dx.doi.org/10.1007/s00262-020-02653-1

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