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DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities

CAR-T transfer, recently well-developed immunotherapy, has offered substantial benefit to more and more patients with advanced cancers. However, along with growing experience in the clinical application comes the increasing awareness of the potentially fatal adverse effects, most notably cytokine re...

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Detalles Bibliográficos
Autores principales: Deng, Tian, Tang, Chao, Zhang, Guizhong, Wan, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838657/
https://www.ncbi.nlm.nih.gov/pubmed/33504767
http://dx.doi.org/10.1038/s41419-021-03428-x