Raltitrexed Inhibits HepG2 Cell Proliferation via G(0)/G(1) Cell Cycle Arrest

Raltitrexed (RTX) is an antimetabolite drug used as a chemotherapeutic agent for treating colorectal cancer, malignant mesothelioma, and gastric cancer. The antitumor capacity of RTX is attributed to its inhibitory activity on thymidylate synthase (TS), a key enzyme in the synthesis of DNA precursor...

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Detalles Bibliográficos
Autores principales: Zhao, Hongwei, Zhang, Yubao, Sun, Jianmin, Zhan, Chao, Zhao, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838684/
https://www.ncbi.nlm.nih.gov/pubmed/27098147
http://dx.doi.org/10.3727/096504016X14562725373671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838684/
https://www.ncbi.nlm.nih.gov/pubmed/27098147
http://dx.doi.org/10.3727/096504016X14562725373671

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