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Raltitrexed Inhibits HepG2 Cell Proliferation via G(0)/G(1) Cell Cycle Arrest

Raltitrexed (RTX) is an antimetabolite drug used as a chemotherapeutic agent for treating colorectal cancer, malignant mesothelioma, and gastric cancer. The antitumor capacity of RTX is attributed to its inhibitory activity on thymidylate synthase (TS), a key enzyme in the synthesis of DNA precursor...

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Detalles Bibliográficos
Autores principales:	Zhao, Hongwei, Zhang, Yubao, Sun, Jianmin, Zhan, Chao, Zhao, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cognizant Communication Corporation 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838684/ https://www.ncbi.nlm.nih.gov/pubmed/27098147 http://dx.doi.org/10.3727/096504016X14562725373671

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