Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates

Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is hyperphosphorylated in Alzheimer's disease,...

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Detalles Bibliográficos
Autores principales: Savastano, Adriana, Flores, David, Kadavath, Harindranath, Biernat, Jacek, Mandelkow, Eckhard, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839466/
https://www.ncbi.nlm.nih.gov/pubmed/33017094
http://dx.doi.org/10.1002/anie.202011157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839466/
https://www.ncbi.nlm.nih.gov/pubmed/33017094
http://dx.doi.org/10.1002/anie.202011157

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