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Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal

The self‐renewal efficiency of mouse embryonic stem cells (ESCs) is determined by the concentration of the transcription factor NANOG. While NANOG binds thousands of sites in chromatin, the regulatory systems that control DNA binding are poorly characterised. Here, we show that NANOG is phosphorylat...

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Detalles Bibliográficos
Autores principales: Mullin, Nicholas P., Varghese, Joby, Colby, Douglas, Richardson, Julia M., Findlay, Greg M., Chambers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839479/
https://www.ncbi.nlm.nih.gov/pubmed/33107035
http://dx.doi.org/10.1002/1873-3468.13969