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Enantioselective Total Synthesis of (−)‐Finerenone Using Asymmetric Transfer Hydrogenation
(−)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6‐step synthesis of (−)‐finerenone, which features an enantiosel...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839499/ https://www.ncbi.nlm.nih.gov/pubmed/32890415 http://dx.doi.org/10.1002/anie.202011256 |