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Enantioselective Total Synthesis of (−)‐Finerenone Using Asymmetric Transfer Hydrogenation

(−)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6‐step synthesis of (−)‐finerenone, which features an enantiosel...

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Detalles Bibliográficos
Autores principales:	Lerchen, Andreas, Gandhamsetty, Narasimhulu, Farrar, Elliot H. E., Winter, Nils, Platzek, Johannes, Grayson, Matthew N., Aggarwal, Varinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839499/ https://www.ncbi.nlm.nih.gov/pubmed/32890415 http://dx.doi.org/10.1002/anie.202011256

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