Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates

Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor‐selective treatment options. A hydrophilic β‐glucuronidase‐cleavable linker was used to connect the highly potent antimitotic ag...

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Detalles Bibliográficos
Autores principales: Anselmi, Michele, Borbély, Adina, Figueras, Eduard, Michalek, Carmela, Kemker, Isabell, Gentilucci, Luca, Sewald, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839693/
https://www.ncbi.nlm.nih.gov/pubmed/32955139
http://dx.doi.org/10.1002/chem.202003471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839693/
https://www.ncbi.nlm.nih.gov/pubmed/32955139
http://dx.doi.org/10.1002/chem.202003471

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