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Autophagy in white matter disorders of the CNS: mechanisms and therapeutic opportunities

Autophagy is a constitutive process that degrades, recycles and clears damaged proteins or organelles, yet, despite activation of this pathway, abnormal proteins accumulate in neurons in neurodegenerative diseases and in oligodendrocytes in white matter disorders. Here, we discuss the role of autoph...

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Detalles Bibliográficos
Autores principales: Nutma, Erik, Marzin, Manuel C, Cillessen, Saskia AGM, Amor, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839724/
https://www.ncbi.nlm.nih.gov/pubmed/33135781
http://dx.doi.org/10.1002/path.5576