Targeting stromal cell Syndecan‐2 reduces breast tumour growth, metastasis and limits immune evasion

Tumour stromal cells support tumourigenesis. We report that Syndecan‐2 (SDC2) is expressed on a nonepithelial, nonhaematopoietic, nonendothelial stromal cell population within breast cancer tissue. In vitro, syndecan‐2 modulated TGFβ signalling (SMAD7, PAI‐1), migration and immunosuppression of pati...

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Detalles Bibliográficos
Autores principales: Loftus, Paul G., Watson, Luke, Deedigan, Laura M., Camarillo‐Retamosa, Eva, Dwyer, Róisín M., O'Flynn, Lisa, Alagesan, Senthilkumar, Griffin, Matthew, O'Brien, Timothy, Kerin, Michael J., Elliman, Stephen J., Barkley, Laura R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Tumor Immunology and Microenvironment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839764/
https://www.ncbi.nlm.nih.gov/pubmed/33152121
http://dx.doi.org/10.1002/ijc.33383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839764/
https://www.ncbi.nlm.nih.gov/pubmed/33152121
http://dx.doi.org/10.1002/ijc.33383

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