Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development

Antibody-drug conjugates (ADC) are effective antibody-based therapeutics for hematopoietic and lymphoid tumors. However, there is need to identify new targets for ADCs, particularly for solid tumors and cancers with unmet needs. From a hybridoma library developed against cancer cells, we selected th...

Descripción completa

Detalles Bibliográficos
Autores principales: Marquez, Jorge, Dong, Jianping, Dong, Chun, Tian, Changsheng, Serrero, Ginette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840024/
https://www.ncbi.nlm.nih.gov/pubmed/33503070
http://dx.doi.org/10.1371/journal.pone.0246197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840024/
https://www.ncbi.nlm.nih.gov/pubmed/33503070
http://dx.doi.org/10.1371/journal.pone.0246197

Ejemplares similares