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Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development

Antibody-drug conjugates (ADC) are effective antibody-based therapeutics for hematopoietic and lymphoid tumors. However, there is need to identify new targets for ADCs, particularly for solid tumors and cancers with unmet needs. From a hybridoma library developed against cancer cells, we selected th...

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Detalles Bibliográficos
Autores principales:	Marquez, Jorge, Dong, Jianping, Dong, Chun, Tian, Changsheng, Serrero, Ginette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840024/ https://www.ncbi.nlm.nih.gov/pubmed/33503070 http://dx.doi.org/10.1371/journal.pone.0246197

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