Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

The antiviral protein kinase R (PKR) is an important host restriction factor, which poxviruses must overcome to productively infect host cells. To inhibit PKR, many poxviruses encode a pseudosubstrate mimic of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), designated K3 in v...

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Detalles Bibliográficos
Autores principales: Park, Chorong, Peng, Chen, Rahman, M. Julhasur, Haller, Sherry L., Tazi, Loubna, Brennan, Greg, Rothenburg, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840043/
https://www.ncbi.nlm.nih.gov/pubmed/33444388
http://dx.doi.org/10.1371/journal.ppat.1009183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840043/
https://www.ncbi.nlm.nih.gov/pubmed/33444388
http://dx.doi.org/10.1371/journal.ppat.1009183

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