Cargando…

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

The antiviral protein kinase R (PKR) is an important host restriction factor, which poxviruses must overcome to productively infect host cells. To inhibit PKR, many poxviruses encode a pseudosubstrate mimic of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), designated K3 in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Chorong, Peng, Chen, Rahman, M. Julhasur, Haller, Sherry L., Tazi, Loubna, Brennan, Greg, Rothenburg, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840043/ https://www.ncbi.nlm.nih.gov/pubmed/33444388 http://dx.doi.org/10.1371/journal.ppat.1009183

Ejemplares similares

Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R
por: Rahman, M. Julhasur, et al.
Publicado: (2022)

Molecular Mechanisms of Poxvirus Evolution
por: Brennan, Greg, et al.
Publicado: (2022)

Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR
por: Rothenburg, Stefan, et al.
Publicado: (2011)

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications
por: Rothenburg, Stefan, et al.
Publicado: (2008)

LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses
por: Rahman, M Julhasur, et al.
Publicado: (2022)

Activation of the Antiviral Kinase PKR and Viral Countermeasures
por: Dauber, Bianca, et al.
Publicado: (2009)

Maladaptation after a virus host switch leads to increased activation of the pro-inflammatory NF-κB pathway
por: Yu, Huibin, et al.
Publicado: (2022)

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
por: Rothenburg, Stefan, et al.
Publicado: (2008)

Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats
por: Bruneau, Ryan C., et al.
Publicado: (2023)

Spontaneous and Engineered Compensatory HSV Mutants that Counteract the Host Antiviral PKR Response
por: Shah, Amish C., et al.
Publicado: (2009)

Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR
por: Dauber, Bianca, et al.
Publicado: (2009)

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication
por: Rahman, Masmudur M., et al.
Publicado: (2013)

PKR: A Kinase to Remember
por: Gal-Ben-Ari, Shunit, et al.
Publicado: (2019)

Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections()
por: Baker, Robert O, et al.
Publicado: (2003)

Hantaviruses use the endogenous host factor P58(IPK) to combat the PKR antiviral response
por: Wang, Zekun, et al.
Publicado: (2021)

LincRNA‐EPS impairs host antiviral immunity by antagonizing viral RNA–PKR interaction
por: Zhu, Jingfei, et al.
Publicado: (2022)

Antiviral Activity of 4′-thioIDU and Thymidine Analogs against Orthopoxviruses
por: Prichard, Mark N., et al.
Publicado: (2010)

CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector
por: Siegrist, Cathryn M., et al.
Publicado: (2020)

Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism
por: Shchelkunov, Sergei N.
Publicado: (2012)

Viral genomic features predict orthopoxvirus reservoir hosts
por: Tseng, Katie K., et al.
Publicado: (2023)

An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A
por: Sadler, Anthony J., et al.
Publicado: (2009)

dsRNA-induced condensation of antiviral proteins modulates PKR activity
por: Corbet, Giulia A., et al.
Publicado: (2022)

Here, There, and Everywhere: The Wide Host Range and Geographic Distribution of Zoonotic Orthopoxviruses
por: Silva, Natalia Ingrid Oliveira, et al.
Publicado: (2020)

PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling
por: Dobrikov, Mikhail I., et al.
Publicado: (2022)

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways
por: Banerjee, Shefali, et al.
Publicado: (2022)

Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection
por: Amantana, Adams, et al.
Publicado: (2013)

Human DICER helicase domain recruits PKR and modulates its antiviral activity
por: Montavon, Thomas C., et al.
Publicado: (2021)

PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis
por: Zuo, Wenjie, et al.
Publicado: (2022)

An Update of Orthopoxvirus Molecular Evolution
por: Babkin, Igor V., et al.
Publicado: (2022)

Comparative Pathology of Zoonotic Orthopoxviruses
por: MacNeill, Amy L.
Publicado: (2022)

Evolution of the orthopoxvirus core genome
por: Molteni, Cristian, et al.
Publicado: (2022)

Positive Regulation of Splicing of Cellular and Viral mRNA by Intragenic RNA Elements That Activate the Stress Kinase PKR, an Antiviral Mechanism
por: Kaempfer, Raymond
Publicado: (2023)

Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range
por: Brennan, Greg, et al.
Publicado: (2014)

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways
por: Banerjee, Shefali, et al.
Publicado: (2022)

Correction: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis
por: Zuo, Wenjie, et al.
Publicado: (2022)

The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors
por: Kicuntod, Jintawee, et al.
Publicado: (2022)

Orthopoxvirus DNA in Eurasian Lynx, Sweden
por: Tryland, Morten, et al.
Publicado: (2011)

An Increasing Danger of Zoonotic Orthopoxvirus Infections
por: Shchelkunov, Sergei N.
Publicado: (2013)

Novel Orthopoxvirus Infection in an Alaska Resident
por: Springer, Yuri P., et al.
Publicado: (2017)

Skin lesions caused by Orthopoxvirus in children
por: Mazur-Melewska, Katarzyna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_icss3dm9mvhh6rfpen85t9qsii