Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ

Heme is the endogenous ligand for the constitutively repressive REV-ERB nuclear receptors, REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), but how heme regulates REV-ERB activity remains unclear. Cellular studies indicate that heme is required for the REV-ERBs to bind the corepressor NCoR and repress transcr...

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Detalles Bibliográficos
Autores principales: Mosure, Sarah A., Strutzenberg, Timothy S., Shang, Jinsai, Munoz-Tello, Paola, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840129/
https://www.ncbi.nlm.nih.gov/pubmed/33571111
http://dx.doi.org/10.1126/sciadv.abc6479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840129/
https://www.ncbi.nlm.nih.gov/pubmed/33571111
http://dx.doi.org/10.1126/sciadv.abc6479

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