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Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ
Heme is the endogenous ligand for the constitutively repressive REV-ERB nuclear receptors, REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), but how heme regulates REV-ERB activity remains unclear. Cellular studies indicate that heme is required for the REV-ERBs to bind the corepressor NCoR and repress transcr...
Autores principales: | Mosure, Sarah A., Strutzenberg, Timothy S., Shang, Jinsai, Munoz-Tello, Paola, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840129/ https://www.ncbi.nlm.nih.gov/pubmed/33571111 http://dx.doi.org/10.1126/sciadv.abc6479 |
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