hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins

Botulinum neurotoxins (BoNTs) are zinc metalloproteases that block neurotransmitter release at the neuromuscular junction (NMJ). Their high affinity for motor neurons combined with a high potency have made them extremely effective drugs for the treatment of a variety of neurological diseases as well...

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Detalles Bibliográficos
Autores principales: Lamotte, Juliette Duchesne De, Roqueviere, Sylvain, Gautier, Hélène, Raban, Elsa, Bouré, Céline, Fonfria, Elena, Krupp, Johannes, Nicoleau, Camille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840483/
https://www.ncbi.nlm.nih.gov/pubmed/33519485
http://dx.doi.org/10.3389/fphar.2020.617867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840483/
https://www.ncbi.nlm.nih.gov/pubmed/33519485
http://dx.doi.org/10.3389/fphar.2020.617867

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