The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor...

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Detalles Bibliográficos
Autores principales: Liu, Yue, Tang, Wenqian, Ji, Chunhui, Gu, Jianghong, Chen, Yanmei, Huang, Jie, Zhao, Xinyi, Sun, Yingfang, Wang, Chengniu, Guan, Wei, Liu, Jianfeng, Jiang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840484/
https://www.ncbi.nlm.nih.gov/pubmed/33519490
http://dx.doi.org/10.3389/fphar.2020.624429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840484/
https://www.ncbi.nlm.nih.gov/pubmed/33519490
http://dx.doi.org/10.3389/fphar.2020.624429

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