Blockade of LAG-3 in PD-L1-Deficient Mice Enhances Clearance of Blood Stage Malaria Independent of Humoral Responses

T cells expressing high levels of inhibitory receptors such as PD-1 and LAG-3 are a hallmark of chronic infections and cancer. Checkpoint blockade therapies targeting these receptors have been largely validated as promising strategies to restore exhausted T cell functions and clearance of chronic in...

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Detalles Bibliográficos
Autores principales: Furtado, Raquel, Chorro, Laurent, Zimmerman, Natalie, Guillen, Erik, Spaulding, Emily, Chin, Shu Shien, Daily, Johanna P., Lauvau, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840658/
https://www.ncbi.nlm.nih.gov/pubmed/33519801
http://dx.doi.org/10.3389/fimmu.2020.576743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840658/
https://www.ncbi.nlm.nih.gov/pubmed/33519801
http://dx.doi.org/10.3389/fimmu.2020.576743

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