Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (withaferin-A and withanone) that have similar...

Descripción completa

Detalles Bibliográficos
Autores principales: Wadhwa, Renu, Yadav, Neetu Singh, Katiyar, Shashank P., Yaguchi, Tomoko, Lee, Chohee, Ahn, Hyomin, Yun, Chae-Ok, Kaul, Sunil C., Sundar, Durai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840742/
https://www.ncbi.nlm.nih.gov/pubmed/33504873
http://dx.doi.org/10.1038/s41598-021-81729-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840742/
https://www.ncbi.nlm.nih.gov/pubmed/33504873
http://dx.doi.org/10.1038/s41598-021-81729-z

Ejemplares similares