Anti-inflammatory potential of Quercetin in COVID-19 treatment

SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine sto...

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Autores principales: Saeedi-Boroujeni, Ali, Mahmoudian-Sani, Mohammad-Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840793/
https://www.ncbi.nlm.nih.gov/pubmed/33509217
http://dx.doi.org/10.1186/s12950-021-00268-6
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author Saeedi-Boroujeni, Ali
Mahmoudian-Sani, Mohammad-Reza
author_facet Saeedi-Boroujeni, Ali
Mahmoudian-Sani, Mohammad-Reza
author_sort Saeedi-Boroujeni, Ali
collection PubMed
description SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Phylogenetic findings show more similarity of the SARS-CoV-2 virus with bat coronaviruses, and less with SARS-CoV. Quercetin is a carbohydrate-free flavonoid that is the most abundant flavonoid in vegetables and fruits and has been the most studied to determine the biological effects of flavonoids. Inflammasomes are cytosolic multi-protein complexes assembling in response to cytosolic PAMP and DAMPs, whose function is to generate active forms of cytokines IL-1β and IL-18. Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2. Quercetin suppresses the NLRP3 inflammasome by affecting these regulators. Quercetin, as an anti-inflammatory, antioxidant, analgesic and inflammatory compound, is probably a potential treatment for severe inflammation and one of the main life-threatening conditions in patients with COVID-19.
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spelling pubmed-78407932021-01-28 Anti-inflammatory potential of Quercetin in COVID-19 treatment Saeedi-Boroujeni, Ali Mahmoudian-Sani, Mohammad-Reza J Inflamm (Lond) Hypothesis SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Phylogenetic findings show more similarity of the SARS-CoV-2 virus with bat coronaviruses, and less with SARS-CoV. Quercetin is a carbohydrate-free flavonoid that is the most abundant flavonoid in vegetables and fruits and has been the most studied to determine the biological effects of flavonoids. Inflammasomes are cytosolic multi-protein complexes assembling in response to cytosolic PAMP and DAMPs, whose function is to generate active forms of cytokines IL-1β and IL-18. Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2. Quercetin suppresses the NLRP3 inflammasome by affecting these regulators. Quercetin, as an anti-inflammatory, antioxidant, analgesic and inflammatory compound, is probably a potential treatment for severe inflammation and one of the main life-threatening conditions in patients with COVID-19. BioMed Central 2021-01-28 /pmc/articles/PMC7840793/ /pubmed/33509217 http://dx.doi.org/10.1186/s12950-021-00268-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Hypothesis
Saeedi-Boroujeni, Ali
Mahmoudian-Sani, Mohammad-Reza
Anti-inflammatory potential of Quercetin in COVID-19 treatment
title Anti-inflammatory potential of Quercetin in COVID-19 treatment
title_full Anti-inflammatory potential of Quercetin in COVID-19 treatment
title_fullStr Anti-inflammatory potential of Quercetin in COVID-19 treatment
title_full_unstemmed Anti-inflammatory potential of Quercetin in COVID-19 treatment
title_short Anti-inflammatory potential of Quercetin in COVID-19 treatment
title_sort anti-inflammatory potential of quercetin in covid-19 treatment
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840793/
https://www.ncbi.nlm.nih.gov/pubmed/33509217
http://dx.doi.org/10.1186/s12950-021-00268-6
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