Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the enzyme recognizes and processes RNA remains poorly u...

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Detalles Bibliográficos
Autores principales: Pillon, Monica C., Frazier, Meredith N., Dillard, Lucas B., Williams, Jason G., Kocaman, Seda, Krahn, Juno M., Perera, Lalith, Hayne, Cassandra K., Gordon, Jacob, Stewart, Zachary D., Sobhany, Mack, Deterding, Leesa J., Hsu, Allen L., Dandey, Venkata P., Borgnia, Mario J., Stanley, Robin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840905/
https://www.ncbi.nlm.nih.gov/pubmed/33504779
http://dx.doi.org/10.1038/s41467-020-20608-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840905/
https://www.ncbi.nlm.nih.gov/pubmed/33504779
http://dx.doi.org/10.1038/s41467-020-20608-z

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