Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation

The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that a mutation in the SH3gl1 gene encoding the endocytic protein Endophilin A2 is assoc...

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Detalles Bibliográficos
Autores principales: Norin, Ulrika, Rintisch, Carola, Meng, Liesu, Forster, Florian, Ekman, Diana, Tuncel, Jonatan, Klocke, Katrin, Bäcklund, Johan, Yang, Min, Bonner, Michael Y., Lahore, Gonzalo Fernandez, James, Jaime, Shchetynsky, Klementy, Bergquist, Maria, Gjertsson, Inger, Hubner, Norbert, Bäckdahl, Liselotte, Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840939/
https://www.ncbi.nlm.nih.gov/pubmed/33504785
http://dx.doi.org/10.1038/s41467-020-20586-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840939/
https://www.ncbi.nlm.nih.gov/pubmed/33504785
http://dx.doi.org/10.1038/s41467-020-20586-2

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