A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

The blood-brain barrier (BBB) is critical for neural function. We report here circadian regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with highest levels during the active phase and lowest during the resting phase. This oscillation is abrogated in circadian c...

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Detalles Bibliográficos
Autores principales: Zhang, Shirley L., Lahens, Nicholas F., Yue, Zhifeng, Arnold, Denice M., Pakstis, Peter P., Schwarz, Jessica E., Sehgal, Amita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841146/
https://www.ncbi.nlm.nih.gov/pubmed/33504784
http://dx.doi.org/10.1038/s41467-020-20795-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841146/
https://www.ncbi.nlm.nih.gov/pubmed/33504784
http://dx.doi.org/10.1038/s41467-020-20795-9

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