Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations

Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes (CMs) derived from them. Half maxim...

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Detalles Bibliográficos
Autores principales: Burkert, Karsten, Taheri, Hadiseh, Hamad, Sarkawt, Oliverio, Matteo, Peinkofer, Gabriel, Kornfeld, Jan-Wilhelm, Harnying, Wacharee, Pfannkuche, Kurt, Hescheler, Jürgen, Berkessel, Albrecht, Šarić, Tomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841182/
https://www.ncbi.nlm.nih.gov/pubmed/33504837
http://dx.doi.org/10.1038/s41598-021-81351-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841182/
https://www.ncbi.nlm.nih.gov/pubmed/33504837
http://dx.doi.org/10.1038/s41598-021-81351-z

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