Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds

Volume of distribution at steady state (V(D,ss)) is one of the key pharmacokinetic parameters estimated during the drug discovery process. Despite considerable efforts to predict V(D,ss), accuracy and choice of prediction methods remain a challenge, with evaluations constrained to a small set (<1...

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Detalles Bibliográficos
Autores principales: Murad, Neha, Pasikanti, Kishore K., Madej, Benjamin D., Minnich, Amanda, McComas, Juliet M., Crouch, Sabrinia, Polli, Joseph W., Weber, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841422/
https://www.ncbi.nlm.nih.gov/pubmed/33239335
http://dx.doi.org/10.1124/dmd.120.000202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841422/
https://www.ncbi.nlm.nih.gov/pubmed/33239335
http://dx.doi.org/10.1124/dmd.120.000202

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