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Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
Volume of distribution at steady state (V(D,ss)) is one of the key pharmacokinetic parameters estimated during the drug discovery process. Despite considerable efforts to predict V(D,ss), accuracy and choice of prediction methods remain a challenge, with evaluations constrained to a small set (<1...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841422/ https://www.ncbi.nlm.nih.gov/pubmed/33239335 http://dx.doi.org/10.1124/dmd.120.000202 |