ACTA1 is inhibited by PAX3-FOXO1 through RhoA-MKL1-SRF signaling pathway and impairs cell proliferation, migration and tumor growth in Alveolar Rhabdomyosarcoma

BACKGROUND: Alveolar Rhabdomyosarcoma (ARMS) is a pediatric malignant soft tissue tumor with skeletal muscle phenotype. Little work about skeletal muscle proteins in ARMS was reported. PAX3-FOXO1 is a specific fusion gene generated from the chromosomal translocation t (2;13) (q35; q14) in most ARMS....

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Detalles Bibliográficos
Autores principales: Hu, Qiande, Zhu, Liang, Li, Yuan, Zhou, Jianjun, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842031/
https://www.ncbi.nlm.nih.gov/pubmed/33509264
http://dx.doi.org/10.1186/s13578-021-00534-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842031/
https://www.ncbi.nlm.nih.gov/pubmed/33509264
http://dx.doi.org/10.1186/s13578-021-00534-3

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