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ACTA1 is inhibited by PAX3-FOXO1 through RhoA-MKL1-SRF signaling pathway and impairs cell proliferation, migration and tumor growth in Alveolar Rhabdomyosarcoma

BACKGROUND: Alveolar Rhabdomyosarcoma (ARMS) is a pediatric malignant soft tissue tumor with skeletal muscle phenotype. Little work about skeletal muscle proteins in ARMS was reported. PAX3-FOXO1 is a specific fusion gene generated from the chromosomal translocation t (2;13) (q35; q14) in most ARMS....

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Detalles Bibliográficos
Autores principales:	Hu, Qiande, Zhu, Liang, Li, Yuan, Zhou, Jianjun, Xu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842031/ https://www.ncbi.nlm.nih.gov/pubmed/33509264 http://dx.doi.org/10.1186/s13578-021-00534-3

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