Cargando…

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

BACKGROUND: Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. Deregulation of Wnt/β-catenin signaling pathway induces the metabolism switchin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xiao-Ting, Wang, Yu-Han, Cai, Xiao-Yue, Dong, Yun, Cui, Qing, Zhou, Ya-Ning, Yang, Xi-Wen, Lu, Wen-Feng, Zhang, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842072/ https://www.ncbi.nlm.nih.gov/pubmed/33509267 http://dx.doi.org/10.1186/s40170-021-00243-y

Ejemplares similares

RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA
por: Zhang, Zhi-Dong, et al.
Publicado: (2020)

The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection
por: Bilkei‐Gorzo, Orsolya, et al.
Publicado: (2022)

Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma
por: Wei, Chuan-Yuan, et al.
Publicado: (2019)

RNF152 negatively regulates Wnt/β-catenin signaling in Xenopus embryos
por: Yoon, Gang-Ho, et al.
Publicado: (2022)

α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
por: Choi, Seung H., et al.
Publicado: (2013)

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling
por: Callow, Marinella G., et al.
Publicado: (2011)

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer
por: Li, Riyong, et al.
Publicado: (2020)

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway
por: Zhan, Ping, et al.
Publicado: (2017)

The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling
por: Chen, Xi, et al.
Publicado: (2023)

Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions
por: Benary, Uwe, et al.
Publicado: (2013)

RNF146 Inhibits Excessive Autophagy by Modulating the Wnt-β-Catenin Pathway in Glutamate Excitotoxicity Injury
por: Yang, Yuefan, et al.
Publicado: (2017)

Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells
por: Radaszkiewicz, Tomasz, et al.
Publicado: (2020)

RNF43 overexpression attenuates the Wnt/β-catenin signalling pathway to suppress tumour progression in cholangiocarcinoma
por: Pangestu, Norma Sainstika, et al.
Publicado: (2021)

The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function
por: Okamoto, Takumi, et al.
Publicado: (2020)

RNF11 at the Crossroads of Protein Ubiquitination
por: Mattioni, Anna, et al.
Publicado: (2020)

RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma
por: Zeng, Xingdu, et al.
Publicado: (2023)

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin
por: Zebisch, Matthias, et al.
Publicado: (2013)

Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation
por: Wei, Meng, et al.
Publicado: (2022)

RNF2 regulates Wnt/ß-catenin signaling via TCF7L1 destabilization
por: Koo, Youngmu, et al.
Publicado: (2023)

RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma
por: Zhang, Yunfeng, et al.
Publicado: (2019)

Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

Normalization of non‐canonical Wnt signalings does not compromise blood‐brain barrier protection conferred by upregulating endothelial Wnt/β‐catenin signaling following ischemic stroke
por: Ji, Ya‐bin, et al.
Publicado: (2021)

E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING
por: Yang, Lu-Lu, et al.
Publicado: (2022)

RNF115 Inhibits the Post‐ER Trafficking of TLRs and TLRs‐Mediated Immune Responses by Catalyzing K11‐Linked Ubiquitination of RAB1A and RAB13
por: Zhang, Zhi‐Dong, et al.
Publicado: (2022)

USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination
por: Novellasdemunt, Laura, et al.
Publicado: (2017)

Wnt/β-catenin pathway activation and silencing of the APC gene in HPV-positive human cervical cancer-derived cells
por: Ayala-Calvillo, Erick, et al.
Publicado: (2018)

Oxidative Distress Induces Wnt/β-Catenin Pathway Modulation in Colorectal Cancer Cells: Perspectives on APC Retained Functions
por: Catalano, Teresa, et al.
Publicado: (2021)

Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin
por: Erazo-Oliveras, Alfredo, et al.
Publicado: (2023)

Knockdown of SF-1 and RNF31 Affects Components of Steroidogenesis, TGFβ, and Wnt/β-catenin Signaling in Adrenocortical Carcinoma Cells
por: Ehrlund, Anna, et al.
Publicado: (2012)

Jade-1 inhibits Wnt signaling by ubiquitinating β-catenin and mediates Wnt pathway inhibition by pVHL
por: Chitalia, Vipul C., et al.
Publicado: (2008)

BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response
por: Zhao, Hongchang, et al.
Publicado: (2014)

LINC00491 Facilitates Tumor Progression of Lung Adenocarcinoma via Wnt/β-Catenin-Signaling Pathway by Regulating MTSS1 Ubiquitination
por: Wan, Huimin, et al.
Publicado: (2022)

Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
por: Peng, Rui, et al.
Publicado: (2019)

Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway
por: Zhong, Min, et al.
Publicado: (2021)

RNF168 is highly expressed in esophageal squamous cell carcinoma and contributes to the malignant behaviors in association with the Wnt/β-catenin signaling pathway
por: Gou, Yunjiu, et al.
Publicado: (2021)

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis
por: Christie, M, et al.
Publicado: (2013)

Activation of Wnt/β‐catenin signalling is required for TGF‐β/Smad2/3 signalling during myofibroblast proliferation
por: Xu, Liang, et al.
Publicado: (2017)

β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC
por: Fredericks, Ernst, et al.
Publicado: (2018)

SOX17 restrains proliferation and tumor formation by down-regulating activity of the Wnt/β-catenin signaling pathway via trans-suppressing β-catenin in cervical cancer
por: Li, Lu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0vch7tkf0f77omf7ulasovafmm