MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways

Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic leucine zipper kinase gene (MELK) plays an im...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xu, Wang, Jie, Wang, Yifeng, Liu, Guanzheng, Li, Huan, Yu, Jiefeng, Wu, Runqiu, Liang, Jun, Yu, Rutong, Liu, Xuejiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842085/
https://www.ncbi.nlm.nih.gov/pubmed/33520717
http://dx.doi.org/10.3389/fonc.2020.608082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842085/
https://www.ncbi.nlm.nih.gov/pubmed/33520717
http://dx.doi.org/10.3389/fonc.2020.608082

Ejemplares similares